She was never relevant.
She had a mild amount of meme stuff on /co/ and an okayish amount of people here pretended to really like her.
It was all blown out of proportion and half the time people were just trolling and saying they liked her more than they did in order to annoy other people here.
That's exactly what it was, and I participated in it as such.
Her series had the slightest, slightest amount of quality and innovation, about a 2/10, and this actually made it the best Marvel title at the time. People unfamiliar with good comics were thus blown away by 4th-rate-warmed-over-Grant-Morrison-Animal-Man-tactics from literally 30+ years ago and pretended that breaking the fourth wall was a new and interesting concept.
(Also Gwenpool is literally on the level of Linkara's theme song from a decade ago.)
It's a fine fun series but nothing special at all.