It's more that the Patty/Marcie ship was mainstreamed largely by Family Guy depicting them as a lesbian couple in adulthood, which is a giveaway that the writers never actually paid attention to how the characters interact in the comic, and just assumed Marcie calling Patty "sir" = lesbians.
As a result, thousands of normies consider Patty/Marcie a real thing that the comic intended to portray, which is just silly. If a Patty/Marcie shipper can acknowledge the actual comic wasn't depicting them as romantically interested in one another, that's fine. Lots of people have crackships or ships that aren't remotely canon. The issue is when people genuinely believe the ship was part of the comic, which it inarguably wasn't.