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I think specialization is the key to the success of non-4chan imageboards. You don't need to be too specific, as even simple changes like 'no politics' or 'use proper grammar' can eek out a pretty strong niche.
At the same time, though, there's a bit of an issue with the non-4chan boards competing with themselves instead of 4chan, which further increases 4chan's monopoly. The challenge remains: how do you entice the minority of 4chan users that are good to leave their trash pile?