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>Perfectio and Kali Yuga, who are hypostasized concepts that can be repulsed or otherwise made to back off, but can't be beaten in any real capacity.
Once again, Perfectio isn't a hypostasized concept, he's an eldritch entity who feeds on negative power. Stop repeating that annoying bull.
He happens to retain his "invincible" status due to not facing other beings of a equal caliber (yet).
Also, Kali Yuga died for good. Shows that with enough firepower you can permanently kill cosmics.
>Keisar is explicitly stated to have access to *infinite* power, and when you beat him, plainly states "I'll be back, losers".
Neither as powerful as Ouryuoh's true form, the Infinite Powers nor Buster Machine III.
>Supreme Deity Z is ostensibly as close to an all-powerful being as we've gotten, but is ultimately a recreation of a thing that already died once, then dies again for good measure.
Now this guy you're downplaying because its former self died by _suicide_. Dying for good measure can be applied to Kali Yuga who you're so fond of claiming is indestructible.
>Yukimura's still got the record for the most destruction in one attack, but the actual machine itself was pretty unimpressive, with the Origin Unit doing most of the heavy lifting.
If you count SC2's one world, fragmented into many through artificial means, as a real multiverse. Anyway the man himself only claimed to destroy the _world_.